What Claudia says is true for some women. Among the most common estrogen-related effects of the combined pill are headache (cephalea), nausea, vomiting and breast tenderness. The onset of these effects can lead to temporary or permanent issues if the problems don’t diminish with continued use of the method. The advice of gynecologists in these cases is essential in order to offer the woman an equally valid contraceptive solution without the effects of estrogen.