{"id":13982,"date":"2021-09-30T16:25:19","date_gmt":"2021-09-30T14:25:19","guid":{"rendered":"https:\/\/pianetadonna.aogoi.it\/non-categorizzato\/are-folates-essential-nutrients-even-before-conception\/"},"modified":"2024-06-07T13:48:27","modified_gmt":"2024-06-07T11:48:27","slug":"are-folates-essential-nutrients-even-before-conception","status":"publish","type":"post","link":"https:\/\/pianetadonna.aogoi.it\/en\/pregnancy-prevention\/folic-acid-why-its-important-to-think-ahead\/are-folates-essential-nutrients-even-before-conception\/","title":{"rendered":"ARE FOLATES ESSENTIAL NUTRIENTS EVEN BEFORE CONCEPTION?"},"content":{"rendered":"<p><span>It has been confirmed for some time that folates are essential micronutrients even before conception as they prevent the risk of birth defects related to non-closure of the fetal neural tube. <br \/> <strong>Adequate folate supplementation before planning a pregnancy increases the chances of a successful pregnancy and good fetal health.<\/strong> <\/span><\/p>\n<p>\u00a0<\/p>\n<p><span>As recommended by the <strong>Italian Network for Folic Acid Promotion<\/strong>, women of childbearing age who anticipate or do not exclude pregnancy should take an additional <strong>400 micrograms per day <\/strong>(0.4 mg\/day) of <strong>vitamin B9<\/strong> starting at least 1 month before conception and up to the third month of pregnancy (<strong>periconceptional period<\/strong>).<\/span><\/p>\n<p>\u00a0<\/p>\n<p><strong><span>Folate<\/span><\/strong><span> has been shown to have a beneficial effect on ovarian function, although the exact mechanism has yet to be identified. <\/span><\/p>\n<p><span>Several studies have shown <strong>the importance of the proportion of folate and homocysteine amino acid concentrations in the maturing microenvironment of the oocyte (female reproductive cell), i.e., in the follicular fluid<\/strong>. <br \/> An excess of <strong>homocysteine<\/strong> and\/or a lack of <strong>folic acid<\/strong> could in fact compromise the adequate maturation of the oocyte and the correct development of the embryo (embryogenesis). It has also been shown that <strong>folate<\/strong> and <strong>homocysteine<\/strong> are present in the follicular fluid (liquid that surrounds the oocyte during its maturation phase) as a proportion in circulating blood levels.<\/span><\/p>\n<p>\u00a0<\/p>\n<p><strong><span>Folate<\/span><\/strong><span> also contributes to the reduction of homocysteine concentration via a methionine remethylation reaction (displacement of a methyl -CH\u2083 group from one molecule to another). The <strong>lack of folate<\/strong> thus leads to an increase in the concentration of <strong>homocysteine<\/strong>. High concentrations of homocysteine in the follicular fluid can be detrimental to the quality and maturation of the oocyte, with a consequent negative impact on embryo fertilization, implantation and development. <strong>The microenvironment of the maturing oocyte is thus positively influenced by folate.<\/strong><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Decidedly YES, so supplementation is recommended before planning a pregnancy.<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[533,532],"tags":[],"class_list":["post-13982","post","type-post","status-publish","format-standard","hentry","category-folic-acid-why-its-important-to-think-ahead","category-pregnancy-prevention"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>ARE FOLATES ESSENTIAL NUTRIENTS EVEN BEFORE CONCEPTION? 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